PTMA - morinlab/LLMPP GitHub Wiki
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PTMA
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| DLBCL |
GAMBL genomes |
0.38 |
| DLBCL |
Schmitz cohort |
0.21 |
| DLBCL |
Reddy cohort |
0.20 |
| DLBCL |
Chapuy cohort |
0.43 |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
Yes |
No |
3.010 |
0 |
| DLBCL |
Yes |
No |
3.468 |
0 |
| FL |
Yes |
No |
0.000 |
0 |
aSHM regions
| chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
| chr2 |
232572640 |
232574297 |
TSS |
NA |
include:tables/browser_PTMA.md
Expression
References