PTEN - morinlab/LLMPP GitHub Wiki

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

PTEN

History

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timeline
    title Publication timing
      2012-12-01 : Love : BL
      2017-10-10 : Reddy : DLBCL
      2018-05-01 : Chapuy : DLBCL

Relevance tier by entity

Entity Tier Description
BL 1 high-confidence BL gene [@loveGeneticLandscapeMutations2012]
DLBCL 1 high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017; @chapuyMolecularSubtypesDiffuse2018b]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 4.16
BL Thomas cohort 4.70
BL Panea cohort 4.00
DLBCL GAMBL genomes 3.82
DLBCL Schmitz cohort 4.26
DLBCL Reddy cohort 3.10
DLBCL Chapuy cohort 4.70

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No Yes 22.104 81.225
DLBCL No No 4.548 76.677
FL No No 4.634 0.000

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

PTEN Expression

References