POU2F2 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
POU2F2
History
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timeline
title Publication timing
2012-03-06 : Lohr : DLBCL
2013-01-01 : Zhang : DLBCL
2017-01-26 : Krysiak : FL
2017-10-10 : Reddy : DLBCL
2018-05-01 : Chapuy : DLBCL
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012a; @zhangGeneticHeterogeneityDiffuse2013; @reddyGeneticFunctionalDrivers2017] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier1.png) |
1 |
high-confidence FL gene [@krysiakRecurrentSomaticMutations2017b] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
5.93 |
DLBCL |
Schmitz cohort |
6.38 |
DLBCL |
Reddy cohort |
3.40 |
DLBCL |
Chapuy cohort |
6.41 |
FL |
GAMBL genomes |
6.24 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
3.431 |
0.000 |
DLBCL |
No |
Yes |
12.445 |
51.943 |
FL |
No |
No |
17.646 |
0.000 |
POU2F2 Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr19 |
42600031 |
C>G |
Q238H |
chr19 |
42600031 |
C>A |
Q238H |
chr19 |
42600030 |
T>C |
T239A |
chr19 |
42600030 |
T>A |
T239S |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/POU2F2_NM_002698.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/POU2F2.svg)
POU2F2 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/POU2F2_by_pathology.svg)
References