PLCG2 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
PLCG2
History
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timeline
title Publication timing
2019-09-26 : Panea : BL
Relevance tier by entity
Entity |
Tier |
Description |
![BL](https://github.com/morinlab/LLMPP/wiki/images/icons/BL_tier2.png) |
2 |
relevance in BL not firmly established[@paneaWholeGenomeLandscape2019] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
BL |
GAMBL genomes+capture |
3.0 |
BL |
Thomas cohort |
0.8 |
BL |
Panea cohort |
10.9 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.800 |
0.000 |
DLBCL |
No |
No |
2.213 |
14.094 |
FL |
No |
No |
1.491 |
0.000 |
PLCG2 Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr16 |
81819719 |
C>A |
T42N |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/PLCG2_NM_002661.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/PLCG2.svg)
PLCG2 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/PLCG2_by_pathology.svg)
References