PHF6 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
PHF6
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
History
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timeline
title Publication timing
2017-10-10 : Reddy : DLBCL
2023-02-03 : Thomas : BL
Relevance tier by entity
Entity | Tier | Description |
---|---|---|
1 | high-confidence BL gene [@thomasGeneticSubgroupsInform2023] | |
3 | Retired, Failed QC[@reddyGeneticFunctionalDrivers2017] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity | source | frequency (%) |
---|---|---|
BL | GAMBL genomes+capture | 7.16 |
BL | Thomas cohort | 5.50 |
BL | Panea cohort | 5.90 |
DLBCL | GAMBL genomes | 2.49 |
DLBCL | Schmitz cohort | 1.49 |
DLBCL | Reddy cohort | 1.40 |
DLBCL | Chapuy cohort | 0.85 |
Mutation pattern and selective pressure estimates
Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
---|---|---|---|---|
BL | No | Yes | 10.853 | 196.689 |
DLBCL | No | No | 6.130 | 36.559 |
FL | No | No | 31.614 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
PHF6 Expression
All Mutations
Reddy_2135T Reddy_2190T Reddy_2191T Reddy_2470T Reddy_2475T Reddy_2482T Reddy_2628T Reddy_2764T Reddy_2778T Reddy_2788T Reddy_3403T Reddy_3422T Reddy_3508T Reddy_3548T Reddy_3557T Reddy_3603T Reddy_3725T Reddy_3955T Reddy_823T