NF1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
NF1
History
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timeline
title Publication timing
2013-01-01 : Zhang : DLBCL
2017-10-10 : Reddy : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier2.png) |
2 |
relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013; @reddyGeneticFunctionalDrivers2017] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
2.87 |
DLBCL |
Schmitz cohort |
4.04 |
DLBCL |
Reddy cohort |
2.50 |
DLBCL |
Chapuy cohort |
2.14 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
1.485 |
0.000 |
DLBCL |
No |
No |
1.135 |
2.469 |
FL |
No |
No |
0.000 |
0.000 |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/NF1_NM_000267.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/NF1.svg)
NF1 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/NF1_by_pathology.svg)
References