MYOM2 - morinlab/LLMPP GitHub Wiki
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MYOM2
Overview
The prevalence of MYOM2 mutations in DLBCL varies across studies. The role of these mutations in lymphomagenesis has not been thoroughly explored.
History
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timeline
title Publication timing
2011-07-31 : Pasqualucci : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence DLBCL gene[@pasqualucciAnalysisCodingGenome2011] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.25 |
| DLBCL | Schmitz cohort | 8.09 |
| DLBCL | Reddy cohort | 3.20 |
| DLBCL | Chapuy cohort | 4.27 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.021 | 0.000 |
| DLBCL | No | No | 0.893 | 2.648 |
| FL | No | No | 0.649 | 12.057 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
MYOM2 Expression
