MYO1E - morinlab/LLMPP GitHub Wiki
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MYO1E
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| DLBCL |
GAMBL genomes |
2.49 |
| DLBCL |
Schmitz cohort |
3.40 |
| DLBCL |
Reddy cohort |
3.00 |
| DLBCL |
Chapuy cohort |
1.28 |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
Yes |
No |
0.516 |
12.845 |
| DLBCL |
Yes |
No |
0.913 |
14.181 |
| FL |
Yes |
No |
3.818 |
29.467 |
aSHM regions
| chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
| chr15 |
59658991 |
59671152 |
TSS |
NA |
include:tables/browser_MYO1E.md
Expression
References