MTOR - morinlab/LLMPP GitHub Wiki

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @zhangGeneticHeterogeneityDiffuse2013, @reddyGeneticFunctionalDrivers2017, @paneaWholeGenomeLandscape2019,

Overview

Although mutations in MTOR have been reported in DLBCL and some BL, their role in lymphomagenesis has not been thoroughly studied.

Experimental Evidence

Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a gain of function (GOF).[@grabinerDiverseArrayCancerassociated2014]

Relevance tier by entity

include:tables/table1_MTOR.md

Warnings

<<Warn("The variants reported in this gene in BL failed QC")>>

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_MTOR.md

BL

include:tables/BL_MTOR.md

Mutation pattern and selective pressure estimates

include:tables/dnds_MTOR.md

MTOR Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr1	11169376	A>T	I2500N

include:tables/browser_MTOR.md

Expression

Representative Mutations

BL

Rating ★ ☆ ☆ ☆ ☆

include:tables/mermaid_MTOR.md