---

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

MSH2

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2017-10-10 : Reddy : DLBCL

Relevance tier by entity

Entity	Tier	Description
	3	Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	1.72
DLBCL	Schmitz cohort	0.85
DLBCL	Reddy cohort	1.50
DLBCL	Chapuy cohort	0.43

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.680	0
DLBCL	No	No	2.838	0
FL	No	No	3.261	0

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MSH2 Expression

All Mutations

Reddy_2093T Reddy_2106T Reddy_2107T Reddy_2208T Reddy_2224T Reddy_2256T Reddy_2271T Reddy_2483T Reddy_2602T Reddy_2646T Reddy_2784T Reddy_2805T Reddy_2808T Reddy_2838T Reddy_2909T Reddy_2917T Reddy_2936T Reddy_2956T Reddy_3405T Reddy_3453T Reddy_3456T Reddy_3488T Reddy_3585T Reddy_3609T Reddy_3620T Reddy_3622T Reddy_3629T Reddy_3638T Reddy_3674T Reddy_3823T Reddy_3919T Reddy_3930T Reddy_3932T Reddy_3963T Reddy_658T Reddy_799T

References