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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

MAP2K1

History

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timeline
    title Publication timing
      2015-03-01 : Shin : DLBCL
      2016-08-25 : Louissaint : FL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in DLBCL not firmly established[@shinBRAFV600EMAP2K12015]
	1	high-confidence FL gene [@louissaintPediatrictypeNodalFollicular2016a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	1.34
DLBCL	Schmitz cohort	3.19
DLBCL	Reddy cohort	2.20
DLBCL	Chapuy cohort	2.14
FL	GAMBL genomes	1.39

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	4.318	0
DLBCL	No	No	11.932	0
FL	No	No	5.696	0

MAP2K1 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr15	66727441	T>C	F53L
chr15	66727454	A>C	K57T

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MAP2K1 Expression

References