MAP2K1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @louissaintPediatrictypeNodalFollicular2016, @shinBRAFV600EMAP2K12015,
Experimental Evidence
Driver mutations affecting this gene in FL have been experimentally demonstrated to cause a gain of function (GOF).[@schmidtMutationsMAP2K1Are2017]
Relevance tier by entity
include:tables/table1_MAP2K1.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
include:tables/DLBCL_MAP2K1.md
FL
Mutation pattern and selective pressure estimates
MAP2K1 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr15 | 66727441 | T>C | F53L |
| chr15 | 66727454 | A>C | K57T |
include:tables/browser_MAP2K1.md
Expression
include:tables/mermaid_MAP2K1.md