LYN - morinlab/LLMPP GitHub Wiki


bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @chapuyMolecularSubtypesDiffuse2018,

TOC

Overview

LYN mutations have been reported in DLBCL but the rate is relatively rare in most cohorts. The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations. Without further support, this gene may be migrated to Tier 2.

Relevance tier by entity

include:tables/table1_LYN.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.29
DLBCL Schmitz cohort 1.70
DLBCL Reddy cohort 1.30
DLBCL Chapuy cohort 5.56

Mutation pattern and selective pressure estimates

include:tables/dnds_LYN.md

include:tables/browser_LYN.md

Expression

All Mutations

DLBCL-RICOVER_1081-Tumor DLBCL-RICOVER_181-Tumor DLBCL-RICOVER_773-Tumor

include:tables/mermaid_LYN.md

References