LYN - morinlab/LLMPP GitHub Wiki
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LYN
Overview
LYN mutations have been reported in DLBCL but the rate is relatively rare in most cohorts. The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations. Without further support, this gene may be migrated to Tier 2.
History
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timeline
title Publication timing
2018-05-01 : Chapuy : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | low-confidence DLBCL gene[@chapuyMolecularSubtypesDiffuse2018b] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.29 |
| DLBCL | Schmitz cohort | 1.70 |
| DLBCL | Reddy cohort | 1.30 |
| DLBCL | Chapuy cohort | 5.56 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.641 | 0.000 |
| DLBCL | No | No | 10.031 | 17.456 |
| FL | No | No | 0.000 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
LYN Expression
All Mutations
DLBCL-RICOVER_1081-Tumor DLBCL-RICOVER_181-Tumor DLBCL-RICOVER_773-Tumor