LPP - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
LPP
History
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timeline
title Publication timing
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier2.png) |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
1.15 |
DLBCL |
Schmitz cohort |
1.28 |
DLBCL |
Reddy cohort |
1.30 |
DLBCL |
Chapuy cohort |
0.85 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
Yes |
No |
0 |
0 |
DLBCL |
Yes |
No |
0 |
0 |
FL |
Yes |
No |
0 |
0 |
aSHM regions
chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
chr3 |
187771678 |
187801626 |
TSS-1 |
NA |
chr3 |
187801627 |
187813568 |
TSS-2 |
NA |
chr3 |
187813569 |
187955254 |
TSS-3 |
NA |
chr3 |
187955255 |
187969220 |
TSS-4 |
NA |
chr3 |
188261523 |
188327097 |
TSS-5 |
NA |
chr3 |
188377178 |
188401951 |
intron-1 |
NA |
chr3 |
188401952 |
188461879 |
intron-2 |
NA |
chr3 |
188461880 |
188474683 |
intron-3 |
NA |
chr3 |
188474684 |
188491248 |
intron-4 |
NA |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/LPP_NM_005578.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/LPP.svg)
LPP Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/LPP_by_pathology.svg)
References