bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
KRAS mutations are rare but occur in some cases of DLBCL.1 These often affect the most common KRAS hotspot sites that are mutated in other solid cancers (G12 and G13).
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timeline
title Publication timing
2012-03-06 : Lohr : DLBCL
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Entity
Tier
Description
1
high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012a]
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity
source
frequency (%)
DLBCL
GAMBL genomes
1.91
DLBCL
Schmitz cohort
3.62
DLBCL
Reddy cohort
1.70
DLBCL
Chapuy cohort
2.56
Mutation pattern and selective pressure estimates
Entity
aSHM
Significant selection
dN/dS (missense)
dN/dS (nonsense)
BL
No
No
27.314
0
DLBCL
No
No
5.336
0
FL
No
No
9.959
0
Chromosome
Coordinate (hg19)
ref>alt
HGVSp
chr12
25398285
C>A
G12C
chr12
25398284
C>T
G12D
chr12
25398284
C>A
G12V
chr12
25398282
C>A
G13C
chr12
25398281
C>T
G13D
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38