KRAS - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @lohrDiscoveryPrioritizationSomatic2012,
Overview
KRAS mutations are rare but occur in some cases of DLBCL.[@lohrDiscoveryPrioritizationSomatic2012] These often affect the most common KRAS hotspot sites that are mutated in other solid cancers (G12 and G13).
Experimental Evidence
Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a gain of function (GOF).[@scheffzekRasRasGAPComplexStructural1997]
Relevance tier by entity
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
Mutation pattern and selective pressure estimates
KRAS Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr12 | 25398285 | C>A | G12C |
| chr12 | 25398284 | C>T | G12D |
| chr12 | 25398284 | C>A | G12V |
| chr12 | 25398282 | C>A | G13C |
| chr12 | 25398281 | C>T | G13D |
include:tables/browser_KRAS.md
Expression
include:tables/mermaid_KRAS.md