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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

KLHL21

History

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timeline
    title Publication timing
      2018-04-12 : Schmitz : DLBCL

Relevance tier by entity

Entity	Tier	Description
	2-a	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@schmitzGeneticsPathogenesisDiffuse2018a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	3.82
DLBCL	Schmitz cohort	4.68
DLBCL	Reddy cohort	2.50
DLBCL	Chapuy cohort	0.85

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	0.000	0
DLBCL	Yes	No	1.741	0
FL	Yes	No	0.000	0

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr1	6661482	6662702	TSS	NA

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

KLHL21 Expression

References