KLHL14 (Kelch-like family member 14) is a gene that has been identified as playing a role in B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL).¹ KLHL14 has been identified as a recurrent target of somatic mutations in ABC DLBCLs. These mutations are a feature of the MCD genetic subgroup of DLBCL. The gene encodes a protein involved in the ubiquitin-proteasome system, and its inactivation leads to increased cell proliferation and survival, suggesting its role as a tumor suppressor.² KLHL14 loss has been shown to BCR-dependent NF-κB activation and cell survival in DLBCL.² This gene has some mutation hotspots but the patter of mutation overall is consistent with its role as a tumor suppressor gene.

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timeline
    title Publication timing
      2013-01-01 : Zhang : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL

Entity	Tier	Description
	1	high-confidence DLBCL gene[@zhangGeneticHeterogeneityDiffuse2013; @reddyGeneticFunctionalDrivers2017; @schmitzGeneticsPathogenesisDiffuse2018a]

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38