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IL16

Overview

The IL16 gene, which encodes a pro-inflammatory cytokine, plays a role in immune responses. IL-16 is highly expressed in the activated B-cell-like (ABC) subtype of DLBCL compared to the germinal center B-cell-like (GCB) subtype. The role of mutations in lymphomagenesis is not understood. Overall, the mutation rate of IL16 is relatively low in DLBCL. Without further support, this gene may be migrated to Tier 2.

Relevance tier by entity

include:tables/table1_IL16.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.29
DLBCL	Schmitz cohort	3.83
DLBCL	Reddy cohort	2.80
DLBCL	Chapuy cohort	5.13

Mutation pattern and selective pressure estimates

include:tables/dnds_IL16.md

include:tables/browser_IL16.md

Expression

References