HLA DQA1 - morinlab/LLMPP GitHub Wiki

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HLA-DQA1

History

Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.¹

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timeline
    title Publication timing
      2021-05-05 : Hübschmann : DLBCL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence DLBCL gene[@hubschmannMutationalMechanismsShaping2021b]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	0.38
DLBCL	Schmitz cohort	0.64
DLBCL	Reddy cohort	0.30
DLBCL	Chapuy cohort	1.28

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0	0
DLBCL	No	No	0	0
FL	No	No	0	0

HLA-DQA1 Expression

All Mutations

SP116606 SP124957 SP192807 SP193072 SP193150 SP59424

References

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