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HLA-DMB

Overview

HLA-DMB, along with HLA-DMA, plays a critical role in the proper functioning of HLA class II molecules. These genes are essential for the loading of antigenic peptides onto HLA class II molecules, facilitating the presentation of these peptides to CD4+ T cells. Mutations in this gene were first described in DLBCL by Hübschmann et al.[@hubschmannMutationalMechanismsShaping2021]

Relevance tier by entity

include:tables/table1_HLA-DMB.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_HLA-DMB.md

Mutation pattern and selective pressure estimates

include:tables/dnds_HLA-DMB.md

include:tables/browser_HLA-DMB.md

Expression

References