HIST2H2BE - morinlab/LLMPP GitHub Wiki

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

HIST2H2BE

Overview

This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.

History

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timeline
    title Publication timing
      2018-04-12 : Schmitz : DLBCL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence DLBCL gene[@schmitzGeneticsPathogenesisDiffuse2018a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.49
DLBCL	Schmitz cohort	3.19
DLBCL	Reddy cohort	2.60
DLBCL	Chapuy cohort	2.99

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	3.780	40.980
DLBCL	No	No	0.601	3.291
FL	No	No	3.156	0.000

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38