GRHPR is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations. Coding and non-coding mutations in GRHPR are a feature of the MCD genetic subgroup of DLBCL.1 Further research is needed to elucidate the specific role of GRHPR mutations in DLBCL.
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2018-10-01 : Arthur : DLBCL
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1-a
aSHM target and high-confidence DLBCL gene[@arthurGenomewideDiscoverySomatic2018]
Mutation incidence in large patient cohorts (GAMBL reanalysis)