GRHPR - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @arthurGenomewideDiscoverySomatic2018,
Overview
GRHPR is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations. Coding and non-coding mutations in GRHPR are a feature of the MCD genetic subgroup of DLBCL.[@arthurGenomewideDiscoverySomatic2018] Further research is needed to elucidate the specific role of GRHPR mutations in DLBCL.
Relevance tier by entity
include:tables/table1_GRHPR.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
Mutation pattern and selective pressure estimates
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr9 | 37423010 | 37425279 | TSS | active_promoter |
include:tables/browser_GRHPR.md
Expression
include:tables/mermaid_GRHPR.md