GRB2 - morinlab/LLMPP GitHub Wiki
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GRB2
Overview
GRB2 (Growth factor receptor-bound protein 2) is an adaptor protein that links receptor tyrosine kinases to the Ras signaling pathway through its SH2 and SH3 domains. The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations. While direct evidence of GRB2 mutations in DLBCL is limited, its established role in other cancers and signal transduction pathways suggests that it may contribute to lymphomagenesis. Further research is needed to elucidate its specific role in DLBCL.
History
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timeline
title Publication timing
2011-07-31 : Pasqualucci : DLBCL
Relevance tier by entity
Entity | Tier | Description |
---|---|---|
1 | high-confidence DLBCL gene [@pasqualucciAnalysisCodingGenome2011] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity | source | frequency (%) |
---|---|---|
DLBCL | GAMBL genomes | 3.25 |
DLBCL | Schmitz cohort | 2.77 |
DLBCL | Reddy cohort | 1.50 |
DLBCL | Chapuy cohort | 2.99 |
Mutation pattern and selective pressure estimates
Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
---|---|---|---|---|
DLBCL | No | Yes | 33.029 | 168.982 |
FL | No | No | 8.575 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38