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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

GNAS

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2017-10-10 : Reddy : DLBCL

Relevance tier by entity

Entity	Tier	Description
	3	Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.29
DLBCL	Schmitz cohort	3.19
DLBCL	Reddy cohort	1.90
DLBCL	Chapuy cohort	1.28

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	3.064	13.8
DLBCL	No	No	0.967	0.0
FL	No	No	1.581	0.0

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

GNAS Expression

All Mutations

Reddy_2073T Reddy_2095T Reddy_2137T Reddy_2234T Reddy_2253T Reddy_2451T Reddy_2453T Reddy_2479T Reddy_2482T Reddy_2630T Reddy_2639T Reddy_2644T Reddy_2659T Reddy_2775T Reddy_2784T Reddy_2837T Reddy_2838T Reddy_2905T Reddy_2933T Reddy_2999T Reddy_3479T Reddy_3507T Reddy_3523T Reddy_3548T Reddy_3586T Reddy_3602T Reddy_3608T Reddy_3630T Reddy_3636T Reddy_3663T Reddy_3674T Reddy_3712T Reddy_3719T Reddy_3728T Reddy_3742T Reddy_3749T Reddy_3820T Reddy_3834T Reddy_3882T Reddy_3886T Reddy_3913T Reddy_3929T Reddy_3945T Reddy_3977T Reddy_816T

References