FOXP1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
FOXP1
History
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timeline
title Publication timing
2017-10-10 : Reddy : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2-a | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@reddyGeneticFunctionalDrivers2017] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 0.57 |
| DLBCL | Schmitz cohort | 3.62 |
| DLBCL | Reddy cohort | 2.10 |
| DLBCL | Chapuy cohort | 2.99 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 1.218 | 9.469 |
| DLBCL | Yes | No | 7.387 | 17.777 |
| FL | Yes | No | 0.000 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr3 | 71104986 | 71119518 | TSS-4 | active_promoter |
| chr3 | 71176427 | 71180960 | TSS-3 | active_promoter |
| chr3 | 71350633 | 71357665 | TSS-2 | active_promoter |
| chr3 | 71503103 | 71504870 | intron-1b | intron |
| chr3 | 71550753 | 71551478 | intron-1a | intron |
| chr3 | 71626341 | 71635648 | TSS-1 | active_promoter |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
FOXP1 Expression
