FL_genes - morinlab/LLMPP GitHub Wiki

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1, high-confidence FL genes

54 total

Gene Summary First FL study Other entities QC result
ACTB Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@lohrDiscoveryPrioritizationSomatic2012; @wienandGenomicAnalysesFlowsorted2019]
ARID1A Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@barisicARID1AOrchestratesSWI2024] Krysiak et al [@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @wienandGenomicAnalysesFlowsorted2019; @zhangGeneticHeterogeneityDiffuse2013]
ATP6AP1 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016] Okosun et al
ATP6V1B2 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016] Okosun et al
B2M Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivation2011] Morin et al [@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015]
BCL10 Tier 1 GE[@russler-germainMutationsAssociatedProgression2023], FE[@xiaBCL10MutationsDefine2022] Russler-germain et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016]
BCL2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@burkhardtClinicalRelevanceMolecular2022; @sarkozyMutationalLandscapeGray2021; @tanakaFrequentIncidenceSomatic1992]
BCL6 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@masclePointMutationsBCL62003], aSHM Dreval et al [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BCL7A Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015]
BTK Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@huFollicularLymphomaassociatedBTK2021] Krysiak et al [@albuquerqueEnhancingKnowledgeDiscovery2017]
CARD11 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@lenzOncogenicCARD11Mutations2008] Morin et al [@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012]
CCND3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@schmitzBurkittLymphomaPathogenesis2012] Morin et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012]
CD83 Tier 1 GE[@russler-germainMutationsAssociatedProgression2023], aSHM Russler-germain et al [@dunsCharacterizationDLBCLPMBL2021; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019]
CREBBP Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] Pasqualucci et al [@dunsCharacterizationDLBCLPMBL2021; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CTSS Tier 1 GE[@barariaCathepsinAlterationsInduce2020] Bararia et al
EBF1 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@ramirez-komoSpontaneousLossLineage2017], aSHM Dreval et al [@bohleRoleEarlyBcell2013; @reichelFlowSortingExome2015; @thomasGeneticSubgroupsInform2023]
EEF1A1 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@chapuyMolecularSubtypesDiffuse2018; @reichelFlowSortingExome2015]
EP300 Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] Pasqualucci et al [@rossiCodingGenomeSplenic2012]
EZH2 Tier 1 GE[@morinSomaticMutationsAltering2010], FE[@sneeringerCoordinatedActivitiesWildtype2010] Morin et al [@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019]
FAS Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@wangFasFADDDeathDomain2010] Morin et al [@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016]
FOXO1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations] Morin et al [@dunsCharacterizationDLBCLPMBL2021; @schmitzBurkittLymphomaPathogenesis2012]
GNA13 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014] Morin et al [@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015]
GNAI2 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@muppidiLossSignalingGa132014] Dreval et al [@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]
HIST1H1B Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@chapuyMolecularSubtypesDiffuse2018; @sarkozyMutationalLandscapeGray2021]
HIST1H1C Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@paneaWholeGenomeLandscape2019]
HIST1H1D Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@jalladesExomeSequencingIdentifies2017; @morinMutationalStructuralAnalysis2013]
HIST1H1E Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012; @reichelFlowSortingExome2015]
HIST1H2AC Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@morinMutationalStructuralAnalysis2013]
HIST1H2AG Tier 1 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al [@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012]
HIST1H2AM Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@chapuyMolecularSubtypesDiffuse2018; @paneaWholeGenomeLandscape2019]
HIST1H2BC Tier 1 GE[@krysiakRecurrentSomaticMutations2017], aSHM Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012; @mottokIntegrativeGenomicAnalysis2019]
HIST1H2BG Tier 1 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al
HVCN1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018]
IRF4 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019]
IRF8 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@qiuIRF8mutantCellLymphoma2024], aSHM Morin et al [@mottokIntegrativeGenomicAnalysis2019; @paneaWholeGenomeLandscape2019]
KLHL6 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@choiLossKLHL6Promotes2018], aSHM Morin et al [@ganapathiGeneticLandscapeDural2016]
KMT2D Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@zhangDisruptionKMT2DPerturbs2015] Morin et al [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012]
MAP2K1 Tier 1 GE[@louissaintPediatrictypeNodalFollicular2016] Louissaint et al [@shinBRAFV600EMAP2K12015]
MEF2B Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@ponMEF2BMutationsNonHodgkin2015], aSHM Morin et al [@beaLandscapeSomaticMutations2013]
MYC Tier 1 GE, FE[@freieGermlinePointMutation2024], aSHM [@dunsCharacterizationDLBCLPMBL2021; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001]
PIM1 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@kuoRolePIM1Ibrutinibresistant2016], aSHM Dreval et al [@burkhardtClinicalRelevanceMolecular2022; @dunsCharacterizationDLBCLPMBL2021; @pasqualucciHypermutationMultipleProtooncogenes2001]
POU2AF1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@gonzalez-rinconUnravelingTransformationFollicular2019], aSHM Krysiak et al [@chapuyMolecularSubtypesDiffuse2018]
POU2F2 Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@hodsonRegulationNormalBcell2016] Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012]
RRAGC Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016], FE[@okosunRecurrentMTORC1activatingRRAGC2016] Okosun et al
SGK1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@gaoSGK1MutationsDLBCL2021], aSHM Morin et al [@dunsCharacterizationDLBCLPMBL2021]
SMARCA4 Tier 1 GE[@krysiakRecurrentSomaticMutations2017], FE[@fernandoFunctionalCharacterizationSMARCA42020] Krysiak et al [@nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012]
SOCS1 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@melznerBiallelicMutationSOCS12005], aSHM Dreval et al [@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006]
STAT6 Tier 1 GE[@yildizActivatingSTAT6Mutations2015], FE[@mentzPARP14NovelTarget2022] Yildiz et al [@ritzRecurrentMutationsSTAT62009]
TBL1XR1 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@venturuttiTBL1XR1MutationsDrive2020] Dreval et al [@lohrDiscoveryPrioritizationSomatic2012; @rossiCodingGenomeSplenic2012]
TMSB4X Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@reddyGeneticFunctionalDrivers2017]
TNFAIP3 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@compagnoMutationsMultipleGenes2009] Dreval et al [@compagnoMutationsMultipleGenes2009; @rossiAlterationBIRC3Multiple2011; @schmitzTNFAIP3A20Tumor2009]
TNFRSF14 Tier 1 GE[@cheungAcquiredTNFRSF14Mutations2010], FE[@] Cheung et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016]
TP53 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@katoUnderstandingFunctionstructureFunctionmutation2003] Morin et al [@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012; @tiacciPervasiveMutationsJAKSTAT2018; @wildaInactivationARFMDM2p53Pathway2004]
VMA21 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al

Tier 2, low-confidence FL genes

59 total

Gene Summary First FL study Other entities QC result
ABL2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
ACTG1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021], aSHM Hubschmann et al [@deschGenotypingCirculatingTumor2020; @fanComprehensiveCharacterizationDriver2020; @spinaGeneticsNodalMarginal2016]
ATP6V1A Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
BIRC6 Tier 2 GE [@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021]
BTG1 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@almasmoumFrequentLossBTG12021], aSHM Dreval et al [@burkhardtClinicalRelevanceMolecular2022; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021]
BTG2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
CD70 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023], FE[@nieDualRoleCD702022] Russler-germain et al [@morinFrequentMutationHistonemodifying2011]
CD79B Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@davisChronicActiveBcellreceptor2010] Dreval et al [@davisChronicActiveBcellreceptor2010; @paneaWholeGenomeLandscape2019]
CDC42BPB Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@spinaGeneticsNodalMarginal2016]
CILP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
CPNE8 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
CXCR4 Tier 2 GE[@krysiakRecurrentSomaticMutations2017], FE[@zmajkovicovaGenotypephenotypeCorrelationsWHIM2022], aSHM Krysiak et al [@khodabakhshiRecurrentTargetsAberrant2012; @paneaWholeGenomeLandscape2019]
CYP2A6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
DDX3X Tier 2 GE, FE[@gongSequentialInverseDysregulation2021] [@mottokIntegrativeGenomicAnalysis2019; @reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]
DHX15 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
DTX1 Tier 2 GE, aSHM [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]
DUSP2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@dunsCharacterizationDLBCLPMBL2021; @lohrDiscoveryPrioritizationSomatic2012]
EGR1 Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al [@reichelFlowSortingExome2015; @rossiCodingGenomeSplenic2012]
FZR1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
GBP7 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
GRM6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
HIST1H2BD Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al
HIST1H2BM Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al
HIST1H3B Tier 2 GE, aSHM [@lohrDiscoveryPrioritizationSomatic2012; @reichelFlowSortingExome2015]
HIST1H3G Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al
HIST1H3I Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al [@paneaWholeGenomeLandscape2019]
HLA-B Tier 2 GE, FE[@fangazioGeneticMechanismsHLAI2021] [@lohrDiscoveryPrioritizationSomatic2012; @wienandGenomicAnalysesFlowsorted2019]
IGLL5 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023], aSHM Russler-germain et al [@chapuyMolecularSubtypesDiffuse2018; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
ITPKB Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@tiacciPervasiveMutationsJAKSTAT2018], aSHM Dreval et al [@reichelFlowSortingExome2015; @schmitzGeneticsPathogenesisDiffuse2018]
JUP Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
KIR3DL1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
KLF2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]
LAPTM5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021], aSHM Hubschmann et al
LTB Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM Dreval et al [@chapuyMolecularSubtypesDiffuse2018; @deschGenotypingCirculatingTumor2020]
MAGEC1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
MAP7D1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
MEF2C Tier 2 GE, aSHM [@hubschmannMutationalMechanismsShaping2021]
MGEA5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
MKI67 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al [@schmitzBurkittLymphomaPathogenesis2012]
MYCBP2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
MYD88 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@ngoOncogenicallyActiveMYD882011] Dreval et al [@ngoOncogenicallyActiveMYD882011; @yanBCRTLRSignaling2012]
NFKBIA Tier 2 GE[@russler-germainMutationsAssociatedProgression2023], FE[@jungnickelClonalDeleteriousMutations2000] Russler-germain et al [@thomasMutationalAnalysisIkappaBalpha2004; @wienandGenomicAnalysesFlowsorted2019]
OR8H2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
P2RY8 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@muppidiLossSignalingGa132014] Dreval et al [@lohrDiscoveryPrioritizationSomatic2012; @muppidiLossSignalingGa132014]
PDS5B Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@morinMutationalStructuralAnalysis2013]
PPP4C Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
PRKDC Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@schmitzGeneticsPathogenesisDiffuse2018]
PTPRD Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@spinaGeneticsNodalMarginal2016]
PZP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
RBM6 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
S1PR2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@muppidiLossSignalingGa132014], aSHM Dreval et al [@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014]
SHROOM3 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
SRRM2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al [@morinMutationalStructuralAnalysis2013]
STAB2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
TMEM30A Tier 2 GE[@morinFrequentMutationHistonemodifying2011], FE[@ennishiTMEM30ALossoffunctionMutations2020] Morin et al
TPP1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
XIRP2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023] Russler-germain et al
ZC3H12A Tier 2 GE, FE[@skalniakRegulatoryFeedbackLoop2009] [@chapuyMolecularSubtypesDiffuse2018]
ZNF608 Tier 2 GE[@krysiakRecurrentSomaticMutations2017] Krysiak et al [@morinMutationalStructuralAnalysis2013]

Tier 3, retired FL genes

0 total

Gene Summary First FL study Other entities QC result

References