DCAF6 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @reddyGeneticFunctionalDrivers2017,
Overview
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@reddyGeneticFunctionalDrivers2017] Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
Relevance tier by entity
include:tables/table1_DCAF6.md
Warnings
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.15 |
| DLBCL | Schmitz cohort | 2.34 |
| DLBCL | Reddy cohort | 1.30 |
| DLBCL | Chapuy cohort | 1.28 |
Mutation pattern and selective pressure estimates
include:tables/browser_DCAF6.md
Expression
All Mutations
Reddy_2085T Reddy_2124T Reddy_2125T Reddy_2133T Reddy_2162T Reddy_2209T Reddy_2215T Reddy_2236T Reddy_2242T Reddy_2467T Reddy_2468T Reddy_2565T Reddy_2606T Reddy_2611T Reddy_2766T Reddy_2772T Reddy_2829T Reddy_2919T Reddy_2921T Reddy_2999T Reddy_3409T Reddy_3432T Reddy_3479T Reddy_3536T Reddy_3548T Reddy_3607T Reddy_3635T Reddy_3646T Reddy_3679T Reddy_3688T Reddy_3825T Reddy_3915T Reddy_3919T Reddy_3920T Reddy_3974T Reddy_3978T Reddy_3981T Reddy_3987T Reddy_705T
include:tables/mermaid_DCAF6.md