CHST2 - morinlab/LLMPP GitHub Wiki

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

CHST2

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

History

Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.1 Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.

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timeline
    title Publication timing
      2017-10-10 : Reddy : DLBCL

Relevance tier by entity

Entity Tier Description
DLBCL 3 Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 1.34
DLBCL Schmitz cohort 2.34
DLBCL Reddy cohort 0.70
DLBCL Chapuy cohort 0.43

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 0.786 0
DLBCL No No 0.000 0
FL No No 0.000 0

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

CHST2 Expression

All Mutations

Reddy_2073T Reddy_2091T Reddy_2163T Reddy_2204T Reddy_2217T Reddy_2302T Reddy_2459T Reddy_2561T Reddy_2652T Reddy_2687T Reddy_2781T Reddy_2901T Reddy_2912T Reddy_2918T Reddy_2933T Reddy_2953T Reddy_3394T Reddy_3404T Reddy_3467T Reddy_3496T Reddy_3511T Reddy_3632T Reddy_3656T Reddy_3660T Reddy_3672T Reddy_3712T Reddy_3734T Reddy_3736T Reddy_3760T Reddy_3815T Reddy_3834T Reddy_3917T Reddy_3998T

References

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