CHD1 - morinlab/LLMPP GitHub Wiki


bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @reddyGeneticFunctionalDrivers2017,

TOC

Overview

Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@reddyGeneticFunctionalDrivers2017] Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.

Relevance tier by entity

include:tables/table1_CHD1.md

Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.10
DLBCL Schmitz cohort 2.98
DLBCL Reddy cohort 2.90
DLBCL Chapuy cohort 2.14

Mutation pattern and selective pressure estimates

include:tables/dnds_CHD1.md

include:tables/browser_CHD1.md

Expression

include:tables/mermaid_CHD1.md

References