CD274 - morinlab/LLMPP GitHub Wiki


bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @morinFrequentMutationHistonemodifying2011,

TOC

Overview

the CD274 gene encodes the programmed death-ligand 1 (PD-L1). Mutations in B-cell lymphomas, such as DLBCL, are relatively rare. Although rare, mutations have the potential to impact PD-L1 expression and could be relevant in the context of immune checkpoint inhibitors.

Relevance tier by entity

include:tables/table1_CD274.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 0.96
DLBCL Schmitz cohort 2.34
DLBCL Reddy cohort 1.30
DLBCL Chapuy cohort 2.56

Mutation pattern and selective pressure estimates

include:tables/dnds_CD274.md

include:tables/browser_CD274.md

Expression

include:tables/mermaid_CD274.md

References