CD274 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @morinFrequentMutationHistonemodifying2011,
Overview
the CD274 gene encodes the programmed death-ligand 1 (PD-L1). Mutations in B-cell lymphomas, such as DLBCL, are relatively rare. Although rare, mutations have the potential to impact PD-L1 expression and could be relevant in the context of immune checkpoint inhibitors.
Relevance tier by entity
include:tables/table1_CD274.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity | source | frequency (%) |
---|---|---|
DLBCL | GAMBL genomes | 0.96 |
DLBCL | Schmitz cohort | 2.34 |
DLBCL | Reddy cohort | 1.30 |
DLBCL | Chapuy cohort | 2.56 |
Mutation pattern and selective pressure estimates
include:tables/browser_CD274.md
Expression
include:tables/mermaid_CD274.md