Caspase-8 mutations are relatively rare but have been documented in various non-Hodgkin lymphomas (NHLs). One study found no CASP8 mutations in gastrointestinal lymphomas, suggesting that these mutations may not be prevalent in all lymphoma types. Due to the rarity of these mutations, their role remains poorly understood. Loss of caspase-8 may promote lymphomagenesis by impairing cytokinesis and increasing chromosomal aberrations.

Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.¹

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timeline
    title Publication timing
      2017-10-10 : Reddy : DLBCL

Entity	Tier	Description
	1	high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017]

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38