BL_genes - morinlab/LLMPP GitHub Wiki
title: 'BL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
Origins of BL genes
Tier 1, high-confidence BL genes
32 total
| Gene | Summary | First BL study | Other entities | QC result |
|---|---|---|---|---|
| ARID1A | Tier 1 GE[@loveGeneticLandscapeMutations2012], FE[@barisicARID1AOrchestratesSWI2024] | Love et al | [@krysiakRecurrentSomaticMutations2017; @rossiCodingGenomeSplenic2012; @wienandGenomicAnalysesFlowsorted2019; @zhangGeneticHeterogeneityDiffuse2013] | |
| BACH2 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019] | Grande et al | ||
| BCL6 | Tier 1 GE[@loveGeneticLandscapeMutations2012], FE[@masclePointMutationsBCL62003], aSHM | Love et al | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011] | PASS |
| BCL7A | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM | Grande et al | [@krysiakRecurrentSomaticMutations2017; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015] | |
| BMP7 | Tier 1 GE[@paneaWholeGenomeLandscape2019] | Panea et al | ||
| CCND3 | Tier 1 GE[@richterRecurrentMutationID32012], FE[@schmitzBurkittLymphomaPathogenesis2012] | Richter et al | [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @morinFrequentMutationHistonemodifying2011] | |
| CHD8 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019] | Grande et al | ||
| CREBBP | Tier 1 GE[@loveGeneticLandscapeMutations2012], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] | Love et al | [@dunsCharacterizationDLBCLPMBL2021; @parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011] | PASS |
| DDX3X | Tier 1 GE[@schmitzBurkittLymphomaPathogenesis2012], FE[@gongSequentialInverseDysregulation2021] | Schmitz et al | [@mottokIntegrativeGenomicAnalysis2019; @reddyGeneticFunctionalDrivers2017] | |
| FBXO11 | Tier 1 GE[@richterRecurrentMutationID32012], FE[@duanFBXO11TargetsBCL62011] | Richter et al | [@arthurGenomewideDiscoverySomatic2018; @parryWholeExomeSequencing2013] | |
| FOXO1 | Tier 1 GE[@schmitzBurkittLymphomaPathogenesis2012], FE[@trinhAnalysisFOXO1Mutations] | Schmitz et al | [@dunsCharacterizationDLBCLPMBL2021; @morinFrequentMutationHistonemodifying2011] | |
| GNA13 | Tier 1 GE[@loveGeneticLandscapeMutations2012], FE[@muppidiLossSignalingGa132014] | Love et al | [@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015] | |
| GNAI2 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], FE[@muppidiLossSignalingGa132014] | Grande et al | [@drevalGeneticSubdivisionsFollicular2023; @morinMutationalStructuralAnalysis2013] | |
| HIST1H1E | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], aSHM | Grande et al | [@krysiakRecurrentSomaticMutations2017; @lohrDiscoveryPrioritizationSomatic2012; @reichelFlowSortingExome2015] | |
| HNRNPU | Tier 1 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@reddyGeneticFunctionalDrivers2017] | |
| ID3 | Tier 1 GE[@richterRecurrentMutationID32012] | Richter et al | [@schmitzGeneticsPathogenesisDiffuse2018; @spinaGeneticsNodalMarginal2016] | |
| KMT2D | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], FE[@zhangDisruptionKMT2DPerturbs2015] | Grande et al | [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012] | |
| MYC | Tier 1 GE[@johnstonCmycHypermutationBurkitt1992], FE[@freieGermlinePointMutation2024], aSHM | Johnston et al | [@dunsCharacterizationDLBCLPMBL2021; @jalladesExomeSequencingIdentifies2017; @pasqualucciHypermutationMultipleProtooncogenes2001] | |
| P2RY8 | Tier 1 GE[@muppidiLossSignalingGa132014], FE[@muppidiLossSignalingGa132014] | Muppidi et al | [@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012] | |
| PCBP1 | Tier 1 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| PHF6 | Tier 1 GE[@thomasGeneticSubgroupsInform2023] | Thomas et al | [@reddyGeneticFunctionalDrivers2017] | |
| PTEN | Tier 1 GE[@loveGeneticLandscapeMutations2012], FE[@pfeiferPTENLossDefines2013] | Love et al | [@reddyGeneticFunctionalDrivers2017] | |
| RFX7 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], FE[@weberPiggyBacTransposonTools2019] | Grande et al | [@arthurGenomewideDiscoverySomatic2018] | |
| RHOA | Tier 1 GE[@richterRecurrentMutationID32012], FE[@ohayreInactivatingMutationsGNA132016] | Richter et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
| SIN3A | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019] | Grande et al | [@chapuyMolecularSubtypesDiffuse2018; @rossiCodingGenomeSplenic2012] | |
| SMARCA4 | Tier 1 GE[@richterRecurrentMutationID32012], FE[@fernandoFunctionalCharacterizationSMARCA42020] | Richter et al | [@krysiakRecurrentSomaticMutations2017; @nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017] | |
| TCF3 | Tier 1 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| TCL1A | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], aSHM | Grande et al | [@reddyGeneticFunctionalDrivers2017] | |
| TFAP4 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019] | Grande et al | ||
| TP53 | Tier 1 GE[@wildaInactivationARFMDM2p53Pathway2004], FE[@katoUnderstandingFunctionstructureFunctionmutation2003] | Wilda et al | [@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012; @tiacciPervasiveMutationsJAKSTAT2018] | |
| USP7 | Tier 1 GE[@grandeGenomewideDiscoverySomatic2019] | Grande et al | [@arthurGenomewideDiscoverySomatic2018] | |
| WNK1 | Tier 1 GE[@thomasGeneticSubgroupsInform2023] | Thomas et al | [@hubschmannMutationalMechanismsShaping2021; @jalladesExomeSequencingIdentifies2017] |
Tier 2, low-confidence BL genes
72 total
| Gene | Summary | First BL study | Other entities | QC result |
|---|---|---|---|---|
| ADAMTS5 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| ADNP | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| AGO4 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| ARHGEF1 | Tier 2 GE[@muppidiLossSignalingGa132014] | Muppidi et al | ||
| BCL2 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022], aSHM | Burkhardt et al | [@morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021; @tanakaFrequentIncidenceSomatic1992] | |
| BTG1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022], FE[@almasmoumFrequentLossBTG12021], aSHM | Burkhardt et al | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021] | |
| C16orf48 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| CARD4 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | PASS | |
| CCNF | Tier 2 GE[@abateDistinctViralMutational2015] | Abate et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
| CD79A | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | [@rossiCodingGenomeSplenic2012] | |
| CD83 | Tier 2 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@dunsCharacterizationDLBCLPMBL2021; @morinMutationalStructuralAnalysis2013; @russler-germainMutationsAssociatedProgression2023] | PASS |
| CDC73 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@reddyGeneticFunctionalDrivers2017] | PASS |
| CDKN2A | Tier 2 GE[@grandeGenomewideDiscoverySomatic2019], FE[@kannengiesserFunctionalStructuralGenetic2009] | Grande et al | [@morinMutationalStructuralAnalysis2013; @spinaGeneticsNodalMarginal2016] | |
| CDKN2C | Tier 2 GE[@thomasGeneticSubgroupsInform2023] | Thomas et al | ||
| CHD4 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| CPXM2 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| CXCR4 | Tier 2 GE[@paneaWholeGenomeLandscape2019], FE[@zmajkovicovaGenotypephenotypeCorrelationsWHIM2022], aSHM | Panea et al | [@khodabakhshiRecurrentTargetsAberrant2012; @krysiakRecurrentSomaticMutations2017] | PASS |
| DHCR7 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| E2F2 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| EBF1 | Tier 2 GE[@thomasGeneticSubgroupsInform2023], FE[@ramirez-komoSpontaneousLossLineage2017], aSHM | Thomas et al | [@bohleRoleEarlyBcell2013; @drevalGeneticSubdivisionsFollicular2023; @reichelFlowSortingExome2015] | |
| EDNRB | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| EHD1 | Tier 2 GE[@thomasGeneticSubgroupsInform2023] | Thomas et al | ||
| EIF4A1 | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | ||
| ELP2 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| EPPK1 | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | ||
| ERAP1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| EXOSC6 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| EZH2 | Tier 2 GE[@loveGeneticLandscapeMutations2012], FE[@sneeringerCoordinatedActivitiesWildtype2010] | Love et al | [@morinSomaticMutationsAltering2010; @mottokIntegrativeGenomicAnalysis2019] | PASS |
| FLYWCH1 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| GGTLA4 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | PASS | |
| GTSE1 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| HIST1H3D | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | PASS | |
| HIST1H3I | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@krysiakRecurrentSomaticMutations2017] | PASS |
| HIST1H4J | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@mottokIntegrativeGenomicAnalysis2019] | PASS |
| HLA-DQB1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| IGLL5 | Tier 2 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@chapuyMolecularSubtypesDiffuse2018; @deschGenotypingCirculatingTumor2020; @russler-germainMutationsAssociatedProgression2023] | PASS |
| IKZF3 | Tier 2 GE[@paneaWholeGenomeLandscape2019], FE[@lazarianHotspotMutationTranscription2021] | Panea et al | [@morinFrequentMutationHistonemodifying2011] | PASS |
| IRF8 | Tier 2 GE[@paneaWholeGenomeLandscape2019], FE[@qiuIRF8mutantCellLymphoma2024], aSHM | Panea et al | [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019] | PASS |
| KANK2 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| KLHL26 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| KMT2C | Tier 2 GE[@zhouSporadicEndemicBurkitt2019] | Zhou et al | [@sarkozyMutationalLandscapeGray2021; @zhangGeneticHeterogeneityDiffuse2013; @zhangGenomicLandscapeMantle2014] | |
| MCL1 | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@dunsCharacterizationDLBCLPMBL2021; @reddyGeneticFunctionalDrivers2017] | PASS |
| MIR142 | Tier 2 GE[@grandeGenomewideDiscoverySomatic2019], FE[@trissalMIR142LossofFunctionMutations2018], aSHM | Grande et al | [@kwanhianMicroRNA142Mutated202012] | |
| MKI67 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | [@russler-germainMutationsAssociatedProgression2023] | |
| MYO18A | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| NBEAL1 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | PASS | |
| NCOR2 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | [@sarkozyMutationalLandscapeGray2021; @spinaGeneticsNodalMarginal2016] | |
| NOA1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| P2RY2 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | PASS | |
| PDCD11 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| PIM1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022], FE[@kuoRolePIM1Ibrutinibresistant2016], aSHM | Burkhardt et al | [@drevalGeneticSubdivisionsFollicular2023; @dunsCharacterizationDLBCLPMBL2021; @pasqualucciHypermutationMultipleProtooncogenes2001] | |
| PLCG2 | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@fanComprehensiveCharacterizationDriver2020] | PASS |
| PPP6R2 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| PREX1 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| RANBP6 | Tier 2 GE[@loveGeneticLandscapeMutations2012] | Love et al | PASS | |
| REV3L | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| RNF144B | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | PASS | |
| RPL10 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| S1PR2 | Tier 2 GE[@muppidiLossSignalingGa132014], FE[@muppidiLossSignalingGa132014], aSHM | Muppidi et al | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011] | |
| SAL3 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| TET2 | Tier 2 GE[@thomasGeneticSubgroupsInform2023], FE[@asmarGenomewideProfilingIdentifies2013] | Thomas et al | [@albuquerqueEnhancingKnowledgeDiscovery2017] | |
| TOP2A | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| TTN | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| VWA7 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| WDR90 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| WHAMM | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| WNK2 | Tier 2 GE[@paneaWholeGenomeLandscape2019] | Panea et al | PASS | |
| YY1AP1 | Tier 2 GE[@schmitzBurkittLymphomaPathogenesis2012] | Schmitz et al | ||
| ZAN | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | ||
| ZBTB7A | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al | [@reddyGeneticFunctionalDrivers2017] | |
| ZFP36L1 | Tier 2 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015] | PASS |
| ZNF85 | Tier 2 GE[@burkhardtClinicalRelevanceMolecular2022] | Burkhardt et al |
Tier 3, retired BL genes
70 total
| Gene | Summary | First BL study | Other entities | QC result |
|---|---|---|---|---|
| ACAD9 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| ACE | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| ALPK2 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| ATP2C2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| BRAF | Tier 3 GE[@loveGeneticLandscapeMutations2012], FE[@wanMechanismActivationRAFERK2004] | Love et al | [@tiacciBRAFMutationsHairycell2011] | FAIL |
| BRD4 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| BTG2 | Tier 3 GE[@loveGeneticLandscapeMutations2012], aSHM | Love et al | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011] | FAIL |
| C6orf27 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| CAD | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| CCT6B | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| CD79B | Tier 3 GE[@paneaWholeGenomeLandscape2019], FE[@davisChronicActiveBcellreceptor2010] | Panea et al | [@davisChronicActiveBcellreceptor2010; @drevalGeneticSubdivisionsFollicular2023] | FAIL |
| CDH17 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| COL4A2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| CTCF | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| CYB5D1 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| CYP4F22 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| DLGAP1 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| DNMT1 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| DTX1 | Tier 3 GE[@loveGeneticLandscapeMutations2012], aSHM | Love et al | [@gomezUltraDeepSequencingReveals2023; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| EIF2C4 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| EML2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| ENTPD3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| EPHB2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| ETS1 | Tier 3 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@morinFrequentMutationHistonemodifying2011] | FAIL |
| FAM129B | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| FGFR3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| FTCD | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| FZD3 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| GRIK5 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| HIST1H1C | Tier 3 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@morinFrequentMutationHistonemodifying2011] | FAIL |
| HIST1H2AG | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013; @rossiCodingGenomeSplenic2012] | FAIL |
| HIST1H2AM | Tier 3 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@chapuyMolecularSubtypesDiffuse2018; @krysiakRecurrentSomaticMutations2017] | FAIL |
| HIST1H2BK | Tier 3 GE[@paneaWholeGenomeLandscape2019], aSHM | Panea et al | [@rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| HIST1H3H | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| HIST1H3J | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| ICK | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| ITPR3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@tiacciPervasiveMutationsJAKSTAT2018] | FAIL |
| KCNK10 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| KIFC3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| MAP3K6 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| MME | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| MTOR | Tier 3 GE[@paneaWholeGenomeLandscape2019], FE[@grabinerDiverseArrayCancerassociated2014] | Panea et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| MYH10 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| NOTCH1 | Tier 3 GE[@loveGeneticLandscapeMutations2012], FE[@ryanCellRegulomeLinks2017] | Love et al | [@beaLandscapeSomaticMutations2013; @pasqualucciAnalysisCodingGenome2011; @rossiCodingGenomeSplenic2012] | FAIL |
| NRXN2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| PABPC4L | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| PC | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| PCDHA11 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| PDZRN3 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| PIK3R1 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | [@zhangGeneticHeterogeneityDiffuse2013] | FAIL |
| POLRMT | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| POR | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| PRSS22 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| PTPRN | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| PXDNL | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| RBP3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@lohrDiscoveryPrioritizationSomatic2012] | FAIL |
| RET | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@fanComprehensiveCharacterizationDriver2020] | FAIL |
| SALL3 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | [@zhangGenomicLandscapeMantle2014] | FAIL |
| SAPS2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| SBF1 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| SF3B1 | Tier 3 GE[@loveGeneticLandscapeMutations2012], FE[@cazzolaBiologicClinicalSignificance2013] | Love et al | [@reddyGeneticFunctionalDrivers2017] | FAIL |
| SHANK1 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| SLC29A2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| SNTB2 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| SYNGAP1 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| TBC1D9B | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| TIGD6 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| TPST2 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL | |
| WDR7 | Tier 3 GE[@paneaWholeGenomeLandscape2019] | Panea et al | FAIL | |
| ZNF229 | Tier 3 GE[@loveGeneticLandscapeMutations2012] | Love et al | FAIL |