BLK - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| DLBCL |
GAMBL genomes |
0.57 |
| DLBCL |
Schmitz cohort |
2.34 |
| DLBCL |
Reddy cohort |
0.70 |
| DLBCL |
Chapuy cohort |
0.85 |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
Yes |
No |
0.528 |
0 |
| DLBCL |
Yes |
No |
1.614 |
0 |
| FL |
Yes |
No |
3.528 |
0 |
aSHM regions
| chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
| chr8 |
11347723 |
11355318 |
TSS |
strong_enhancer |
include:tables/browser_BLK.md
Expression
References