UniKin2 – A Universal, Pan Reactome Kinetic Model - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Ambel, W, Tan, LP, Toh, D, Thirunavukarasu, D, Natarajan, K, Ling, MHT. 2025. UniKin2 – A Universal, Pan-Reactome Kinetic Model. International Journal of Research in Medical and Clinical Science 3(2): 77-80.

Link to [PDF].

Here is the permanent [PDF] and [dataset] links to my archive.

Whole-cell kinetic models have been used to describe the dynamic response of metabolic pathways under various conditions or analyse the behaviour of enzymes and metabolic networks. Previously, UniKin1 was developed as a foundational and universal whole-cell kinetic model using data from Kyoto Encyclopaedia of Genes and Genomes (KEGG). However, UniKin1 was relatively small and only consists of 306 metabolites, 310 enzymes, and 566 reactions; thereby, restricted its ability to simulate an entire cellular system. In this study, we expanded on UniKin1 by using all the reaction data from KEGG as of 24 January 2025, into UniKin2 which consisted of 30669 metabolites, 9420 enzymes, and 9420 reactions. Hence, UniKin2 can be potentially used for many different purposes such as research in organism-independent simulations, exploration of host-pathogen interactions and metabolic rewiring of diseases.