Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection Implications to Microbial Antibiotics Resistance. - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Castillo, CFG, Ling, MHT. 2014. Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection: Implications to Microbial Antibiotics Resistance. BioMed Research International 2014, Article ID 648389.

Link to [Abstract], [Full Text] and [PDF].

Here is a permanent link to this [PDF] and [data set] in my own archive.

We examined whether antibiotics resistance will decline after disuse of specific antibiotics under the assumption that there is no fitness cost for maintaining resistance. Our results show that during disuse of the specific antibiotics, a large initial loss and prolonged stabilization of resistance are observed but resistance is not lost to the stage of pre-resistance emergence. This suggests that a pool of partial resistant organisms persist long after withdrawal of selective pressure at a relatively constant proportion. Subsequent re-introduction of the same antibiotics results in rapid re-gain of resistance. Thus, our simulation results suggest that complete elimination of specific antibiotics resistance is unlikely after the disuse of antibiotics, once a resistant pool of micro-organism has been established.