Gene Co Expressions Cannot Predict Protein Protein Interactions in Escherichia coli. - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Chua, MTE, Dumanglas, ABG, Ling, MHT. 2022. Gene Co-Expressions Cannot Predict Protein-Protein Interactions in Escherichia coli. EC Microbiology 18(3): 102-109.

Link to [Abstract] and [PDF].

Here is the permanent [PDF], and [Data set] links to my archive.

Gene co-expression is the correlation of gene expressions across multiple samples or conditions. Significant gene co-expressions have been used to construct gene co-expression networks and used to elucidate biological information. However, the suitability of gene co-expressions in predicting protein-protein interaction is not clear. In this study, ten gene co-expression measures were evaluated for its suitability in predicting PPIs in Escherichia coli. Our results show poor precision (precision ≤ 0.00188). This suggests that gene co-expression alone is not likely to be suitable to predict protein-protein interactions.