Codon Usage Bias is Evolutionarily Conserved. - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Keng, BMH, Chan, OYW, Ling, MHT. 2014. Codon Usage Bias is Evolutionarily Conserved. Asia Pacific Journal of Life Sciences 7(3): 233-242.

Here is a permanent link to this [Abstract and References] in my own archive.

Codon usage bias (CUB) reflects the frequency distribution of codons usage in the genome. Several studies suggest that CUB is based on the combinations, which are most chemically efficient and minimise translational error, show that amongst closely related species, CUB is similar. However, previous studies were mainly carried out on a limited number of related species. This study tests the hypothesis that CUB is evolutionarily conserved, and examines CUB over a large set of organisms. Codon usage distributions from 18 organisms across a diversity of classes were examined. The correlations of codon usage frequencies were calculated between and within classes. Our results demonstrated that Pearson’s correlation between CUBs of different organisms within the same class is significantly higher than random. The correlation between the CUBs of mammals, birds, insects, yeast, and bacteria also corresponded to evolutionary distance. This suggests that CUB is evolutionarily conserved and the degree of conservation corresponds to evolutionary distance.