Ab Initio Whole Cell Kinetic Model of Yarrowia lipolytica CLIB122 (yliYKY24) - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Yeo, KY, Arivazhagan, M, Senthilkumar, A, Saisudhanbabu, T, Le, MA, Wong, TBS, Lukianto, VR, Ling, MHT. 2025. Ab Initio Whole Cell Kinetic Model of Yarrowia lipolytica CLIB122 (yliYKY24). Medicon Medical Sciences 8(4): 01-06.

Link to [PDF].

Here is the permanent [PDF] and [dataset] links to my archive.

Yarrowia lipolytica is an oleaginous yeast with potential probiotics properties that may be engineered for various industrial applications and the presence of mathematical models (genome-scale models or GSMs, and kinetic models or KMs) will be a valuable tool to guide engineering approaches. To date, there are several GSMs for Y. lipolytica but no whole-cell KM. Here, we present a whole cell simulatable KM of Y. lipolytica, yliYKY24, based on the genome of Y. lipolytica CLIB122. The resulting model consists of 931 metabolites, 703 enzymes with corresponding transcriptions and translations, and 856 enzymatic reactions; which can be a baseline model for incorporating other cellular and growth processes, or as a system to examine cellular resource allocations necessary for engineering.