Ab Initio Whole Cell Kinetic Model of Stutzerimonas balearica DSM 6083 (pbmKZJ23) - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Kwan, ZJ, Teo, W, Lum, AKY, Ng, SMH, Ling, MHT. 2024. Ab Initio Whole Cell Kinetic Model of Stutzerimonas balearica DSM 6083 (pbmKZJ23). Acta Scientific Microbiology 7(2): 28-31.

Link to [abstract].

Here is the permanent [PDF] and [Dataset] links to my archive.

Stutzerimonas balearica (formerly, known as Pseudomonas balearica) is an environmentally tolerant bacterium with denitrification and bioremediation capabilities. Hence, it has been studied for industrial applications; such as, high-value chemical production using metabolic engineering or synthetic biology approaches. Mathematical modelling has the potential to predict biological phenotypes under metabolic perturbations, which can be used to guide engineering approaches. However, there is no mathematical model of S. balearica to-date. In this study, we present a whole cell simulatable kinetic model of S. balearica DSM 6083, pbmKZJ23, constructed using ab initio approach by identifying enzymes from its published genome. The resulting model consists of 737 metabolites, 533 enzymes, and 802 reactions; which can be a baseline model for incorporating other cellular and growth processes, or as a system to examine cellular resource allocations necessary for engineering.