Ab Initio Whole Cell Kinetic Model of Streptococcus pneumoniae NCTC 7465 (spnLHP26) - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Perumal, LH, RajKumar, AA, Kang, CKN, Verma, S, Nanthakumarvani, D, Abul-Hasan, S, Ling, MHT. 2026. Ab Initio Whole Cell Kinetic Model of Streptococcus pneumoniae NCTC 7465 (spnLHP26). Clareus Scientific Medical Sciences 3(1): 02-07.

Link to [PDF].

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Streptococcus pneumoniae is a pathogen able to utilize various carbon sources to produce polysaccharide capsule to avoid the immune system, leading to responsible for many life-threatening infections. Kinetic models may be used to examine S. pneumoniae’s carbon utilization but there are no whole-cell kinetic models of S. pneumoniae to date. In this study, we construct a whole-cell kinetic model based on S. pneumoniae NCTC 7465 using its annotated genome. The resulting model, spnLHP26, consists of 460 enzymes catalysing 836 reactions involving 163 metabolites; which may be suitable as a baseline draft model to examine virulence-associated metabolic susceptibilities of S. pneumoniae.