Ab Initio Whole Cell Kinetic Model of Parabacteroides distasonis APCS2 PD (pdiMLD26) - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Dhinakaran, ML, Tay, TZX, Murugesu, S, Cinco, ANL, Srinithiksha, P, Ling, MHT. 2026. Ab Initio Whole Cell Kinetic Model of Parabacteroides distasonis APCS2/PD (pdiMLD26). Acta Scientific Medical Science 10(2): 52-56.

Link to [PDF].

Here is the permanent [PDF] and [dataset] links to my archive.

Parabacteroids distasonis is a key component of the human gut microbiome, and noted for its ability to produce metabolites that are beneficial for overall gut health. Hence, P. distasonis may be a potential target for metabolic engineering, which can benefit from a whole cell kinetic model. Currently, there are no reported kinetic models for the P. distasonis. Therefore, this study aims to create a whole cell simulatable kinetic model of P. distasonis APCS2/PD using an ab initio approach by identifying enzymes from its published genome. The resulting model, pdiMLD26, encompasses of 703 metabolites, 290 enzymes and 752 enzymatic reactions; which acts as a foundational framework for future research.