A 5 Year Systematic Review (2018 to 2022) on The Effectiveness of Mediterranean Diet in Preventing Alzheimer’s Disease - mauriceling/mauriceling.github.io GitHub Wiki

Citation: Azan, NK, Ng, ASY, Samsudi, F, Mazlan, MR, Loh, YK, Ling, MHT. 2023. A 5-Year Systematic Review (2018 to 2022) on The Effectiveness of Mediterranean Diet in Preventing Alzheimer’s Disease. Acta Scientific Nutritional Health 7(2): 79-90.

Link to [abstract].

Here is the permanent [PDF], and [Data Set] links to my archive.

Alzheimer’s disease (AD) is an age-related neuronal disorder characterized by abnormal levels of proteins, beta amyloid (Aβ) and tau, resulting in gradual loss of cognitive functions due to impaired network of neurons in the brain. Past literature has proposed dietary interventions through administration of Mediterranean Diet (MD) as a solution to prevent AD development. A systematic review on the effectiveness of MD in preventing AD is executed up to July 3, 2022, using PubMed as source database within the last 5 years between 2018 to 2022. 131 articles were identified, and 26 articles were included in this review. After analysing the articles, 5 themes were identified to examine the effectiveness of MD: namely, (a) MD adherence and AD risk (b) MD and AD pathological development, (c) MD and cognitive health (d) Mediterranean - DASH Intervention for Neurodegenerative Delay (MIND) diet, and (e) Diet-microbe interaction. MD adherence is a vital factor in achieving successful dietary intervention. Various covariates and demographics affect adherence level. Differing evidence from literature discuss MD’s efficacy in preventing AD. MD is concluded to be effective to a certain extent in preventing Alzheimer’s disease due to various factors such as adherence levels, demographics etc and further longitudinal and randomised control trials (RCT) are warranted.