Home - epigen/MrBiomics GitHub Wiki

Welcome to the MrBiomics wiki!

Here you find:

  • Detailed instructions, including code snippets, on how to use individual MrBiomics Modules.
  • A tutorial on how to use modules within your Snakemake workflows or projects.
  • Module specifications that ensure compatibility, reproducibility, and sustainability.
  • Recipes for the most conceivable standard analyses, including tutorials, e.g., for comprehensive RNA-seq Analysis.

Tip

Use the sidebar for easier navigation.

Slide Deck

Click to view the latest project slide deck.

๐ŸŒŸ Motivation

Three (subjective) key observations at the end of 2021 motivated me to start this project.

  • Increased demand, but limited resources.
    • The balance between data generators and data analysts is getting worse and communication suffers.
    • There is no sustainable framework to preserve complex inventions and best practices.
    • Established innovation methods (e.g., design thinking, fast prototyping, agile concepts,...) can not be leveraged.
  • An increasing number of fields of relevance and interest, but not more time.
    • Staying current in one field is getting harder.
    • Getting into novel fields takes time and is risky.
    • Method development is very competitive and takes a lot of time, hence it requires determination and focus.
  • Reproducibility crisis and recent technological developments.
    • Established analyses/approaches are often โ€œreinventedโ€, leading to irreproducible results.
    • Recent developments in workflow management enable a mindset shift towards software engineering best practices.
    • Compounding effects of re-using established best practices become possible.

๐Ÿ’ก Conference poster

MrBiomics Poster

Conference poster featured at
AITHYRA's Symposium "AI for Life Science" (2025-09)
CSHL Genome Informatics (2025-11)

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