Radiotherapy Outcomes Estimator (ROE) - cerr/CERR GitHub Wiki
The Radiotherapy Outcomes Estimator (ROE) is a plug-in to CERR that allows users to interactively explore the impact of altering dose on Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP).
The ROE interface [1]
ROE supports the following:
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Applying published TCP and NTCP models. Input dose plans are converted to the fraction number or fraction size used in the modeled datasets.
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Incorporating clinical restrictions on NTCP, and dose-volume constraints. The first operative limit for each protocol is displayed by default, with an additional interface to view selected constraints, or to cycle through available constraints in the order of their violation. Expandable tool-tips are available to display the violated constraints, fraction size or fraction number resulting in violation, and the corresponding NTCP and tumor BED.
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Patient-specific prescription selection using published TCP and NTCP models, while taking into account clinical restrictions on DVH factors and NTCPs.
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Fractionation selection by comparing the maximum achievable TCP or BED while meeting normal tissue (NTCP/DVH) constraints, under different fractionation schemes.
- ROE is bundled with CERR. See: installing CERR.
- Iyer, A., et al. ROE (Radiotherapy Outcomes Estimator): An Open-Source Tool for Optimizing Radiotherapy Prescriptions (2023). Computer Methods and Programs in Biomedicine: 107833.