Choice of assembler - aechchiki/SIB_LongReadsWorkshop_Zurich17 GitHub Wiki

The most important aspect of genome assembly is the algorithm that is used. The important genomic features that will will affect the choice are genome size, heterozygosity are proportion of low complexity sequences.

assembler genome_size heterozygosity pros cons
Falcon any any handling variable levels of haplotype divergence hard to install
Canu any low or high elegant read correction, nice assembly reports
HGAP bacterial size usually single contig assembly of bacteria slow, hard to install
Miniasm any low easy to install, super fast to run not that accurate

It is important to mention that for different genomes you might need to consider replacing one of the Overlap-Layout-Consensus steps by an alternative approach that suits to your genome.

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