Vocab. HEMONC - OHDSI/Vocabulary-v5.0 GitHub Wiki
HemOnc
HemOnc.org is a community-driven knowledge and reference base of medical oncology and hematology available as wiki website. An extract of the HemOnc wiki is implemented as standardized Vocabulary for the purpose of having a standard set of concepts to represent chemotherapy regimens as well as their components and qualities.
HemOnc vocabulary features a complex non-linear OWL ontology which is preserved in standardized tables.
Sources
Domain
Concepts in HemOnc vocabulary belong to one of three Domains below:
| Domain | Notes |
|---|---|
| Regimen | concepts represent treatment protocols as combination of antineoplastic and supporting drugs or other therapies administered in certain order. |
| Procedure | concepts represent medical and surgical procedures and therapies as well as their context like line of therapy or intent. |
| Drug | concepts represent singular components of antineoplastic regimens and their attributes. |
| Condition | concepts represent Neoplastic, Immune or Hematological conditions relevant to therapies listed in three sibling domain within the vocabulary. |
Concept Classes by Domain
| Domain | Concept Class | Meaning |
|---|---|---|
| Regimen | Modality | Type and modality of regimens |
| ::: | Regimen | Chemo-, immuno- and radiotherapy regimens. Standard concepts belonging to this domain are intended to be put in episode_concept_id field of Episode table |
| Procedure | Context | Procedures and therapy contexts like line of therapy or intent |
| ::: | Procedure | Medical and surgical procedures |
| Drug | Brand Name | Marketed name of a drug component |
| ::: | Component | Generic molecule name of drug component |
| ::: | Component Class | Pharmaceutical group to which drug components belong |
| ::: | Route | Route of drug administration |
| ::: | Regimen Class | Clinical-pharmacological classificators commonly used in real pratice |
| Condition | Condition | Conepts for hemotological (including immune-mediated) and oncological conditions |
Standard status and mapping
All valid Regimen domain concepts and Procedure Context concepts are Standard and map to self. Component Class concepts serve as Classification concepts.
The remaining concept in HemOnc Vocabulary are non-standard and have mappings to standard concepts when available.
Hierarchy
HemOnc vocabulary has hierarchical relations both internal and to external vocabularies.
Component Class subsumes standard Drug concepts from RxNorm and RxNorm Extension concepts.
Procedure Context, and Regimens and Component Class concepts are also organized in ontological hierarchy.
Non-standard concepts have hierarchical relationships, but they do not participate in forming CONCEPT_ANCESTOR table.
Relationship
HemOnc vocabulary includes complex set of hierarchical and attributive relationships. Such relations show which drug components belong to regimen, which modality regimens belong to or what is the context of the performed procedure.
Important relations from regimens to components:
| Relationship |
|---|
| Has AB-drug cjgt |
| Has AB-drug cjgt Rx |
| Has antineoplastic |
| Has antineopl Rx |
| Has cytotoxic chemo |
| Has cytotox chemo Rx |
| Has endocrine tx |
| Has endocrine tx Rx |
| Has immunosuppressor |
| Has immunosuppr Rx |
| Has immunotherapy |
| Has immunotherapy Rx |
| Has local therapy |
| Has local therap Rx |
| Has pept-drug cjgt |
| Has pept-drg cjg Rx |
| Has radioconjugate |
| Has radiocjgt Rx |
| Has radiotherapy |
| Has radiotherapy Rx |
| Has steroid tx |
| Has steroid tx Rx |
| Has supportive med |
| Has support med Rx |
| Has targeted therapy |
| Has targeted tx Rx |
Please consult CONCEPT_RELATIONSHIP table for full list of relations.