L1 regularization

L1 penalty terms can be used to detect cell type-specific parameters, triggering specific behavior of signaling pathways or gene regulatory networks. Such differences may reveal drug targets that selectively affect only malignant cells while leaving healthy cells unaffected.

• Steiert B., et al. L1 regularization facilitates detection of cell type-specific parameters in dynamical systems. Bioinformatics 32(17), i718-i726, 2016.

The benchmark model used in the publication is located in the folder /Examples/Dream6_L1.

One example of identifying cell type-specific parameters is shown in the example application JAK2/STAT5 signaling model.