Use LiFE to refine a candidate connectome to an optimized connectome - vistalab/vistasoft GitHub Wiki
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The method solves a set of simultaneous linear equations to obtain a weight for each fascicle, and only positively weighted fascicles are retained
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Fascicles in the optimized connectome all contribute to predicting the diffusion data.
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Fascicles are retained only if they are needed to predict the diffusion data.