SPARC - sporedata/researchdesigneR GitHub Wiki

General description

The NIH's Stimulating Peripheral Activity to Relieve Conditions (SPARC) program was designed to transform our understanding of nerve-organ interactions to advance bioelectronic medicine toward treatments that change lives. SPARC bridges the body and the brain.

The SPARC Portal is an open neuroscience and systems physiology platform containing multi-species data, knowledge, computational modeling, and spatial mapping. It provides interactive access to a growing collection of data, maps, and computational studies focusing on the autonomic nervous system's role in controlling organ function. These resources are available to the public to advance bioelectronic medicine toward more precise treatment of diseases and conditions.

Related publications

• High-throughput segmentation of rat unmyelinated axons by deep learning
• Characterization of projections of longitudinal muscle motor neurons in human colon
• Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans
• Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control
• Computational analysis of the human sinus node action potential - Model development and effects of mutations
• Robust 3-Dimensional visualization of human colon enteric nervous system without tissue sectioning

Data access

More information about SPARC can be found at https://sparc.science/