NHCDR - sporedata/researchdesigneR GitHub Wiki

General description

The National Institute of Neurological Disorders and Stroke (NINDS) focuses on providing academic and industry investigators with well-characterized cell sources (fibroblasts and/or induced pluripotent stem cells for Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS), Ataxia-telangiectasia, Frontotemporal Lobar Degeneration (FTD), Huntington's Disease, Parkinson's Disease, and healthy controls) to advance the study of neurological disorders.

The NINDS Human Cell and Data Repository (NHCDR) provides access to fibroblast and/or induced pluripotent stem cell (iPSC) lines for multiple neurological disorders within the NINDS mission and healthy controls. NHCDR also supports access to unique iPSC collections from LEFFTDS, NeuroLINCS, PDBP, and Target ALS with associated metadata.

Related publications

• Vascularized hiPSC-derived 3D cardiac microtissue on chip
• PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
• A highly efficient transgene knock-in technology in clinically relevant cell types
• Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models
• Retrotransposon insertions associated with risk of neurologic and psychiatric diseases
• Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing
• G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly
• Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson's Disease Patient
• Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection
• Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids

Data access

More information about NHCDR can be found at https://nindsgenetics.org/

To access NHCDR catalog, visit https://stemcells.nindsgenetics.org/