BV BRC - sporedata/researchdesigneR GitHub Wiki

General description

The Bacterial and Viral Bioinformatics Resource Center (BV-BRC) is an information system designed to support the biomedical research community’s work on bacterial and viral infectious diseases by integrating vital pathogen information with rich data and analysis tools. BV-BRC combines the data, technology, and extensive user communities from two long-running centers: PATRIC, the bacterial system, and IRD/ViPR, the viral system. Both resources host data on protein structure and function, clinical studies, drug targets and resistance, epidemiology, and other features and provide open-source tools for data analysis and genomic annotation.

BV-BRC is committed to driving big data analytics and pushing the boundaries of bioinformatics tool development to accommodate the evolving needs of the infectious disease research community. BV-BRC is transforming the existing bacterial and viral BRC resources into an integrated, scalable resource for comparative bioinformatics, large-scale data analysis, multi-scale systems biology exploration, integrative data mining and discovery, and machine learning that will serve as a paradigm for NIH data resources moving forward.

Related publications

• Detection of SARS-CoV-2 Omicron variant (B.1.1.529) infection of white-tailed deer
• Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses
• Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer
• SourceFinder: a Machine-Learning-Based Tool for Identification of Chromosomal, Plasmid, and Bacteriophage Sequences from Assemblies
• Defining antigen targets to dissect vaccinia virus and mpox virus-specific T cell responses in humans
• PlasmidHostFinder: Prediction of Plasmid Hosts Using Random Forest
• Evidence of episodic positive selection in Corynebacterium diphtheriae complex of species and its implementations in identification of drug and vaccine targets
• Defining the risk of SARS-CoV-2 variants on immune protection
• A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
• Animal Models of Enterovirus D68 Infection and Disease
• Transmission history of SARS-CoV-2 in humans and white-tailed deer
• Early detection of emerging SARS-CoV-2 variants of interest for experimental evaluation
• Classification of bacterial plasmid and chromosome derived sequences using machine learning
• Introducing the Bacterial and Viral Bioinformatics Resource Center (BV-BRC): a resource combining PATRIC, IRD and ViPR
• Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas

Data access

More information about NSRR can be found at https://www.bv-brc.org/